Articles & Reviews

Association of a functional polymorphism in the CHRFAM7A gene with inflammatory response mediators and neuropathic pain after spinal cord injury. Huang W, Kabbani N, Brannan T, Lin MK, Theiss M, Hamilton J, Ecklund J, Conley YP, Vodovotz Y, Brienza D, Wagner AK, Robbins E, Sowa G, Lipsky R. J Neurotrauma. 2019 Mar 29. doi: 10.1089/neu.2018.6200.

Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of α7 Nicotinic Receptor Intracellular Calcium. King JR, Ullah A, Bak E, Jafri MS, Kabbani N. Mol Pharmacol. 2018 Jun;93(6):601-611.

Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone. King JR, Kabbani N. PLoS One. 2018 May 16;13(5):e0197247.

Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors. Kabbani N, Nichols RA. Trends Pharmacol Sci. 2018 Apr;39(4):354-366. 

Curcumin potentiates the function of human α7-nicotinic acetylcholine receptors expressed in SH-EP1 cells. Nebrisi EE, Al Kury LT, Yang KS, Jayaprakash P, Howarth FC, Kabbani N, Oz M. Neurochem Int. 2018 Mar;114:80-84. 

A G protein-coupled α7 nicotinic receptor regulates signaling and TNF-α release in microglia. King JR, Gillevet TC, Kabbani N. FEBS Open Bio. 2017 Aug 7;7(9):1350-1361.

Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation, cytoskeletal motility, and structural growth. King JR, Kabbani N. J Neurochem. 2016 Aug;138(4):532-45.

Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. Alsharari, SD, King JR, Nordman JC, Muldoon PP, Jackson A,  Zhu AZ, Tyndale RF, Kabbani N, Damaj MI. PLoS One, 2015 Sept 10 10.1371/journal.pone.0137070.

Inhibitory actions of bisabolol on α7-nicotinic acetylcholine receptors. Nurulain S, Prytkova T, Sultan AM, Ievglevskyi O, Lorke D, Yang KH, Petroianu G, Howarth FC, Kabbani N, Oz M. Neuroscience. 2015 Oct 15;306:91-9.

Identification and characterization of a G protein-binding cluster in α7 nicotinic acetylcholine receptors. King JR, Nordman JC, Bridges SP, Lin MK, Kabbani, N. J Biol Chem. 2015 Aug 14;290(33):20060-70

Knowledge-based search and multi-objective filters: proposed structural models of GPCR dimerization. Hashmi, I., Veltri, D., Kabbani, N., Shehu, A. Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics ACM, 2014 Sept 20; 279-288.

Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Nordman JC, Kabbani N. FASEB J. 2014 Jul;28(7):2995-3006.

Chemical crosslinkers enhance detection of receptor interactomes. Corgiat BA, Nordman JC, Kabbani N. Front Pharmacol. 2014 Jan 7;4:171.

Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth. Nordman JC, Phillips WS, Kodama N, Clark SG, Del Negro CA, Kabbani N. J Neurochem. 2013 Dec 18.

The α4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response. Nordman JC, Muldoon P, Clark S, Damaj MI, Kabbani N., Mol Pharmacol. 2014 Jan;85(1):50-61

Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors. Mahgoub M, Keun-Hang SY, Sydorenko V, Ashoor A, Kabbani N, Al Kury L, Sadek B, Howarth CF, Isaev D, Galadari S, Oz M. Eur J Pharmacol. 2013 Nov 15;720(1-3):310-9.

Menthol inhibits 5-HT3 receptor mediated currents. A. Ashoor, J. C. Nordman, D. P. Veltri, K. S. Yang,L. Al Kury,Y. Shuba, M. Mahgoub, F. C. Howarth, C. B. Saddek, A. Shehu, N. Kabbani, M. Oz.. J Pharmacol Exp Ther. 2013 Nov;347(2):398-409.

Are nicotinic acetylcholine receptors coupled to G proteins? N. Kabbani, J. C. Nordman, B. Corgiat, D.P. Veltri, A. Shehu, V. A. Seymour, D. J. Adams. BioEssays 2013 Dec;35(12): 1025-1034.

Not so Cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction.  N. Kabbani. Front. Pharmacol. 23 July 2013  10.3389/fphar.2013.00095.

Menthol attenuates α7-nicotinic acetylcholine receptor function. A. Ashoor, J. C. Nordman,D. P. Veltri, K. S. Yang,L. Al Kury,Y. Shuba, M. Mahgoub, F. C. Howarth, C. Lupica, A. Shehu, N. Kabbani, M. Oz..  PLoS One,  23 Jul 2013 10.1371/journal.pone.0067674.

Capture of D2 dopamine receptor signaling complexes in striatal cells for mass spectrometry proteomic analysis. Kabbani N, Nordman JC. Methods Mol Biol. 2013; 964:43-60.

An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells. Nordman J.C., Kabbani, N. J Cell Sci. 2012 Nov; 125(22): 5502-13.

Dopamine receptor interacting proteins: Targeting neuronal calcium sensor-1/D2 dopamine receptor interaction for antipsychotic drug development. N. Kabbani, M.P. Woll, J.C. Nordman, R.Levenson. Curr Drug Targets. 2012 Jan;13(1):72-9.

Dopamine-Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in Rat Ventral Hippocampus. E. Moreno, S. Vaz, N. Cai, C. Ferrada, C. Quiroz, S. Barodia, N. Kabbani, E. Canela, P. McCormick, C. Lluis, R. Franco, J. Ribeiro, A. Sebastiao, S. Ferre.   J Neurosci. 2011 May 18;31(20):7412-7423.

Differential dopaminergic modulation of neostriatal synaptic connections of striatopallidal axon collaterals. F. Tecuapetla, T. Koos, J. Tepper, N. Kabbani, M. Yeckel.   J Neurosci. 2009 Jul 15;29(28):8977-90.

Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development. J.A. Petko, N. Kabbani, C. Frey, M. Woll, K. Hickey, M. Craig, V.A. Canfield, R. Levenson.  BMC Neurosci. 2009. Mar 25;10(1):27

Proteomics of membrane receptors and signaling. Kabbani N.   Proteomics.  2008. 8 (19): 4146-55.

Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface. Hannan M. A, Kabbani N, Paspalas CD, Levenson R. Biochim Biophys Acta. 2008. 1778(4): 974-982.

Protein interactions in dopamine receptor signaling: from receptor complexes to brain disease.  Kabbani N.  NOVA Science Publishers, 2007. ISBN: 1-60021-915-2.

Intracellular complexes for the b2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Kabbani N, Woll M. P, Levenson R, Lindstrom J. M, Changeux J. P.  Proc Natl Acad Sci USA. 2007. 104(51): 20570-5.

A proteomic approach to receptor signaling: molecular mechanisms and therapeutic implication derived from discovery of the dopamine D2 receptor signalplex. Kabbani N, Levenson R.  Eur J Pharmacol. 2007.  572 (2-3): 83-93.

Antipsychotic induced alterations in D2 dopamine receptor interacting proteins in the cortex. Kabbani N, Levenson R.  Neuroreport. 2006. 17(3): 299-301.

Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. Basile M, Lin R, Kabbani N, Karpa K, Kilimann M, Simpson I, Kester M.  Arch Biochem Biophys. 2006. 446(1): 60-8.

Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear. Blasiole B, Kabbani N, Thisse B, Thisse C, Canfield V, Levenson R.  J. Neurobiol. 2005. 64(3): 285-97.

Unraveling the dopamine receptor signalplex with DRIPs and DRAPs. Kabbani N, Hannan M, Levenson R.  Curr Proteomics. 2005. 2 (3): 209-224.

Dense core vesicle release from PC12 cells regulated by interaction between the D2 dopamine receptor and calcium activator protein for secretion (CAPS). Binda A. V, Kabbani N, Levenson R.  Biochem Pharmacol. 2005. 69(10): 1451-1461.

G protein coupled receptor-protein interactions. Lin R, Kabbani N, Binda A, Canfield V, Levenson R. Receptor Biochemistry and Methodology. John Wiley & Sons, 2004. ISBN: 0471235466.

Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors. Kabbani N, Jeromin A, Levenson R.    Cell Signal. 2004. 16(4):497-503.

Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients. Koh PO, Undie AS, Kabbani N, Levenson R, Goldman-Rakic PS, Lidow MS. Proc Natl Acad Sci USA. 2003. 100(1): 313-317.

Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. Kabbani N, Negyessy L, Lin R, Goldman-Rakic P, Levenson R.  J Neurosci. 2002.  22(19): 8476-8486.

D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Binda A. V, Kabbani N, Lin R, Levenson R.    Mol Pharmacol. 2002. 62 (3): 507-513.

Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Lin R, Karpa K, Kabbani N, Goldman-Rakic P, Levenson R.   Proc Natl Acad Sci USA. 2001. 98 (9): 5258-63.

The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Karpa K, Lin R, Kabbani N, Levenson R.  Mol Pharmacol. 2000.  58 (4): 677-83.

Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. Studer L, Csete M, Lee S. H, Kabbani N, Walikonis J, Wold B, McKay R. D.  J Neurosci. 2000.  20 (19): 7377-83.


Books & Chapters 

R. Lin, N. Kabbani, A. Binda, V. A. Canfield, R. Levenson. 2004. Use of the yeast two-hybrid system to detect receptor-protein interactions. G Protein Coupled Receptor-Protein Interactions. David R. Sibley Ed. Receptor Biochemistry and Methodology. John Wiley & Sons.

N. Kabbani. 2007. Protein interactions in dopamine receptor signaling: from receptor complexes to brain disease. Molecular Interactions of G Protein-Coupled Receptors. Francisco Ciruela Alférez Ed. NOVA Science Publishers.

N. Kabbani, J.C. Nordman. 2013. Capture of D2 dopamine receptor signaling complexes in striatal cells for mass spectrometry proteomic analysis. Methods Mol Biol. Nadine Kabbani Ed. Springer Humana Press.

Dopamine: Methods and Protocols in the Series Methods in Molecular Biology (Ed. Kabbani). Springer Humana Press. 2013. ISBN-10: 1627032525


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