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Real time imaging of dynamic secretory events to define essential genes involved in regulated secretion – 10/20/2014

Dr. Duy Tran Developmental Glycobiology Section, NIDCR, NIH   Regulated secretion is a critical process by which cells deliver molecules to the cell surface and extracellular space. Secreted cargo is synthesized in the endoplasmic reticulum, traverses the Golgi apparatus and is subsequently loaded into secretory vesicles. Secretion occurs in response to an external stimulus and […]

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How positive emotions impact our success and well-being -10/27/2014

Dr. Beth Cabrera Senior Scholar Center for the Advancement of Well-Being George Mason University   Researchers in the field of positive psychology have discovered a number of benefits associated with positive emotions. Dr. Cabrera will discuss how these benefits contribute to success and well-being and will highlight specific strategies that can be used to create […]

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The Panic of 1893 – History, Emotion and Modeling – 9/22/2014

Wayne Zandbergen PhD, George Mason University The Panic of 1893 was the worst economic crisis encountered by the century-old United States. Like the Great Depression, the 1890’s presented a double dip recession with associated bank panics. Unlike the Depression, in 1893 there was little regulatory infrastructure in place to deal with the ensuing economic problems. […]

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Science, Knowledge and Freedom – 9/15/14

Jim Manzi Founder and Chairman, Applied Predictive Technologies Non-experimental social science is not capable of making useful, reliable, and non-obvious predictions for the effects of most social interventions. Social science very likely can improve its practical utility by conducting many more experiments, and should do so. Even with such improvements, however, it will not be […]

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Biogenesis: the emergence of the fourth geosphere -9/8/14

Dr. Eric Smith Krasnow Institute for Advanced Study, George Mason University In most of 20th century Biology, the individual has been the locus of description, whether with regard to selection, development, or ecology. Efforts to understand the origin of life require that we adopt a wider perspective in which life is a planetary process. In […]

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To move or to rest? MRI in the developing brain: from research to clinical applications – 5/5/14

Dr. Paola Pergami Pediatric Neurology, West Virginia University Ischemic injury, including Acute Ischemic Stroke (AIS) and Hypoxic Ischemic Encephalopathy (HIE), remains one of the leading cause of motor and cognitive delay in children. Despite availability of advanced Magnetic Resonance Imaging (MRI) modalities that allow for quantitative measurements of white matter lesions and evaluations of brain connectivity […]

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Tools to study the brain, a choose-your-own-adventure talk – 4/28/14

Dr. Loren Looger Janelia Farm, HHMI Our lab primarily focuses on protein engineering of reagents for the study of neurons in the brain, but the tools have applications in pretty much any organism and cell type.  I will discuss our recent progress in making calcium indicators (e.g. GCaMP), red probes for deep and 2-color imaging […]

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Motion and emotion in the basal ganglia – 4/21/14

Dr. Alexxai Kravitz NIDDK/NIH Two basal ganglia pathways exert opposing control over motor output, such that “direct pathway” neurons promote movement, while “indirect pathway” neurons inhibit movement.  More recently, these pathways have also been implicated in reinforcement and reward.  I will present data supporting the hypothesis that the direct pathway neurons that promote movement also […]

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Principles of multimodal integration in Drosophila larvae – 4/14/14

Dr. Marta Zlatic HHMI Janelia Farm Research Campus Nervous systems combine information from multiple modalities to decrease uncertainty and ambiguity in detecting events in the environment, but the way in which they do so is still unclear. A prerequisite for understanding the logic of multimodal integration is identifying the structural basis of multimodal convergence – […]

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Endocytic Transport as a Means to Overcome Physiological Barriers for Delivery of Nanomedicines – 4/7/14

Dr. Silvia Muro Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering University of Maryland  Apart from their activity, many factors govern the efficacy of therapeutic agents, including solubility in body fluids, circulation half-life, clearance, degradation, etc. Nano-scale drug delivery systems can be designed to modify these parameters and enhance the therapeutic efficacy […]

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