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To move or to rest? MRI in the developing brain: from research to clinical applications – 5/5/14

Dr. Paola Pergami Pediatric Neurology, West Virginia University Ischemic injury, including Acute Ischemic Stroke (AIS) and Hypoxic Ischemic Encephalopathy (HIE), remains one of the leading cause of motor and cognitive delay in children. Despite availability of advanced Magnetic Resonance Imaging (MRI) modalities that allow for quantitative measurements of white matter lesions and evaluations of brain connectivity […]

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Tools to study the brain, a choose-your-own-adventure talk – 4/28/14

Dr. Loren Looger Janelia Farm, HHMI Our lab primarily focuses on protein engineering of reagents for the study of neurons in the brain, but the tools have applications in pretty much any organism and cell type.  I will discuss our recent progress in making calcium indicators (e.g. GCaMP), red probes for deep and 2-color imaging […]

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Motion and emotion in the basal ganglia – 4/21/14

Dr. Alexxai Kravitz NIDDK/NIH Two basal ganglia pathways exert opposing control over motor output, such that “direct pathway” neurons promote movement, while “indirect pathway” neurons inhibit movement.  More recently, these pathways have also been implicated in reinforcement and reward.  I will present data supporting the hypothesis that the direct pathway neurons that promote movement also […]

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Principles of multimodal integration in Drosophila larvae – 4/14/14

Dr. Marta Zlatic HHMI Janelia Farm Research Campus Nervous systems combine information from multiple modalities to decrease uncertainty and ambiguity in detecting events in the environment, but the way in which they do so is still unclear. A prerequisite for understanding the logic of multimodal integration is identifying the structural basis of multimodal convergence – […]

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Endocytic Transport as a Means to Overcome Physiological Barriers for Delivery of Nanomedicines – 4/7/14

Dr. Silvia Muro Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering University of Maryland  Apart from their activity, many factors govern the efficacy of therapeutic agents, including solubility in body fluids, circulation half-life, clearance, degradation, etc. Nano-scale drug delivery systems can be designed to modify these parameters and enhance the therapeutic efficacy […]

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CANCELED DUE TO SNOW – Beyond Single Cells: Quantifying neuronal population activity for basic and therapeutic applications- 3/17/14

Dr. Gene Civillico Science and Engineering Labs, FDA’s Center for Devices and Radiological Health The mechanisms of action of many therapies for nervous system indications are poorly understood. One possible explanation is that effective neurotherapeutics might have their most important effects at the circuit level rather than at the level of single channels or receptors. Without knowing how existing therapies […]

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No Monday Seminar – 3/10/14

There will be no Monday Seminar during Mason’s spring break.  Please join us again on Monday, March 17th.

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CANCELED – 3/3/14 – How positive emotions impact our success and well-being – Dr. Beth Cabrera

Beth helps organizations and individuals apply knowledge from the field of positive psychology to achieve greater success and well-being. She works with companies to build and maintain positive work environments where people thrive. She also helps professional women create happier, more meaningful lives. Dr. Cabrera is a Senior Scholar at the George Mason University Center for […]

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New insights into complex visuosocial representation in the primate cerebral cortex – 2/24/14

Dr. David Leopold Chief, Section on Cognitive Neurophysiology and Imaging Laboratory of Neuropsychology National Institute of Mental Health Several decades of research have revealed exquisite neural selectivity in the monkey inferotemporal cortex for complex visual stimuli, including those related to social perception.  The importance of these selective responses for determining perception, action, and social behavior […]

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Activity-dependent modification of dendrite development and plasticity in Drosophila larval visual system – 2/17/14

Dr. Quan Yuan PI of the Dendrite Morphogenesis and Plasticity Unit, NINDS/NIH Neural plasticity has many forms that express at distinct levels and serve specific functions. Recent studies indicated that, beside the classic hebbian form plasticity, neurons also utilize homeostatic mechanisms to compensate for changes in neuronal activity generated during development or through experience, for […]

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