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Principles of multimodal integration in Drosophila larvae – 4/14/14

Dr. Marta Zlatic HHMI Janelia Farm Research Campus Nervous systems combine information from multiple modalities to decrease uncertainty and ambiguity in detecting events in the environment, but the way in which they do so is still unclear. A prerequisite for understanding the logic of multimodal integration is identifying the structural basis of multimodal convergence – […]

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Endocytic Transport as a Means to Overcome Physiological Barriers for Delivery of Nanomedicines – 4/7/14

Dr. Silvia Muro Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering University of Maryland  Apart from their activity, many factors govern the efficacy of therapeutic agents, including solubility in body fluids, circulation half-life, clearance, degradation, etc. Nano-scale drug delivery systems can be designed to modify these parameters and enhance the therapeutic efficacy […]

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CANCELED DUE TO SNOW – Beyond Single Cells: Quantifying neuronal population activity for basic and therapeutic applications- 3/17/14

Dr. Gene Civillico Science and Engineering Labs, FDA’s Center for Devices and Radiological Health The mechanisms of action of many therapies for nervous system indications are poorly understood. One possible explanation is that effective neurotherapeutics might have their most important effects at the circuit level rather than at the level of single channels or receptors. Without knowing how existing therapies […]

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No Monday Seminar – 3/10/14

There will be no Monday Seminar during Mason’s spring break.  Please join us again on Monday, March 17th.

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CANCELED – 3/3/14 – How positive emotions impact our success and well-being – Dr. Beth Cabrera

Beth helps organizations and individuals apply knowledge from the field of positive psychology to achieve greater success and well-being. She works with companies to build and maintain positive work environments where people thrive. She also helps professional women create happier, more meaningful lives. Dr. Cabrera is a Senior Scholar at the George Mason University Center for […]

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New insights into complex visuosocial representation in the primate cerebral cortex – 2/24/14

Dr. David Leopold Chief, Section on Cognitive Neurophysiology and Imaging Laboratory of Neuropsychology National Institute of Mental Health Several decades of research have revealed exquisite neural selectivity in the monkey inferotemporal cortex for complex visual stimuli, including those related to social perception.  The importance of these selective responses for determining perception, action, and social behavior […]

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Activity-dependent modification of dendrite development and plasticity in Drosophila larval visual system – 2/17/14

Dr. Quan Yuan PI of the Dendrite Morphogenesis and Plasticity Unit, NINDS/NIH Neural plasticity has many forms that express at distinct levels and serve specific functions. Recent studies indicated that, beside the classic hebbian form plasticity, neurons also utilize homeostatic mechanisms to compensate for changes in neuronal activity generated during development or through experience, for […]

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Can connectomics help us understand neural computation? Insights from the fly visual system – 2/10/14

Dmitri “Mitya” Chklovskii Group Leader, Janelia Farm, HHMI Animal behavior arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in the insect visual […]

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On the Therapeutic Mechanisms of Deep Brain Stimulation for Parkinson’s disease: Why High Frequency? – 2/3/14

Dr. Srivedi Sarma Assistant Professor Institute for Computational Medicine Department of Biomedical Engineering Johns Hopkins University Deep brain stimulation (DBS) is clinically recognized to treat movement disorders in Parkinson’s disease (PD), but its therapeutic mechanisms remain elusive. One thing is clear though: high frequency periodic DBS (130-180Hz) is therapeutic, while low frequency DBS (i.e., less than […]

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Indications of Reduced Prefrontal Cortical Function in Chronically Homeless Adults – 1/27/14

Dr. Dale Davidson This study investigated why some homeless individuals seem unable to transition towards self-reliance, following traditional supportive services. It was hypothe- sized that this may be due to some cognitive dysfunction. Chronically homeless adults were compared to controls on three tests of prefrontal competency: the Iowa Gambling Task, Word Fluency (FAS), and the […]

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