Mark M. Rasenick
Distinguished Professor of Physiology & Biophysics and Psychiatry
Director, Biomedical Neuroscience Training Program
Research Service, Jesse Brown VAMC
UIC College of Medicine
GPCR signaling through heterotrimeric G proteins is regulated both by specialized membrane domains (lipid rafts) and cytoskeletal elements, particularly tubulin and microtubules. The role of this interaction will be discussed, with relationship to neurotransmitter action, neuroplasticity and to the possible substrates for both mood and therapeutic intervention for mood disorders.