G protein signaling, the cytoskeleton and the neurobiology of depression and antidepressants – 5/1/2017
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G protein signaling, the cytoskeleton and the neurobiology of depression and antidepressants – 5/1/2017

Monday Seminar, Upcoming Monday Seminars | Comments Off on G protein signaling, the cytoskeleton and the neurobiology of depression and antidepressants – 5/1/2017

Mark M. Rasenick
Distinguished Professor of Physiology & Biophysics and Psychiatry
Director, Biomedical Neuroscience Training Program
Research Service, Jesse Brown VAMC
UIC College of Medicine

Abstract:

GPCR signaling through heterotrimeric G proteins is regulated both by specialized membrane domains (lipid rafts) and cytoskeletal elements, particularly tubulin and microtubules.  The role of this interaction will be discussed, with relationship to neurotransmitter action, neuroplasticity and to the possible substrates for both mood and therapeutic intervention for mood disorders.